Symposium (The 60th Annual Meeting of the Biophysical Society of Japan)
Sep. 28 (13:50~16:20)
Structure and function of “meso-entangled bodies” in the cellYuji Sugita (RIKEN), Hayashi Yamamoto (U. Tokyo)
Proteins often assemble to form “mesoscopic” complexes – some ordered and some disordered – to exert their functions in the cell. Therefore, elucidating their architectures and physical properties is necessary to understand the molecular mechanisms underlying life phenomena and diseases. In this research area “Cross-Scale Biology”, we particularly focus on mesoscopic structures in the range of 20–500 nm (including LLPS condensates), which we define as “meso-entangled bodies (MEBs)”, because MEBs are thought to be key factors that determine the fate of organisms through the transition from disordered to ordered states at the mesoscale. In this symposium, researchers working on the MEBs will gather to discuss the latest technologies and findings, including In-cell AFM, cryo-EM, chemical biology and LLPS.